Caffeine is the most widely used stimulant drug. It can be manufactured and added to various foods and beverages, such as soft drinks, energy drinks, and fatigue-relief pills. It is also used to treat neonatal apnea and is added to painkillers to enhance their effect. Coffee is the most consumed source of caffeine among adults, while tea and soft drinks are more popular among teenagers.
There have long been concerns about coffee increasing the risk of cancer, heart, and vascular problems. However, recent studies have revealed numerous health benefits of coffee. This article will discuss the benefits and drawbacks of coffee on our bodies based on the latest medical research, as outlined by the "Tab Fact" website.
Absorption and Metabolism of Coffee
Chemically, caffeine is known as methylxanthine, which takes approximately 45 minutes to be absorbed in our bodies, reaching its peak in the blood between 15 minutes and 2 hours. Caffeine spreads throughout the body, including the brain. The liver secretes a special enzyme to break down caffeine into smaller compounds, which are converted into uric acid and excreted through urine. Excessive smoking speeds up caffeine metabolism, while pregnancy, especially in the last trimester, slows it down, keeping caffeine in the body for a longer duration.
The activity of the enzyme responsible for caffeine metabolism is partially inherited. Certain medications, including antibiotics, cardiovascular treatments, and some antidepressants, slow down caffeine metabolism. Caffeine may also interact with these medications.
Effects of Caffeine on Bodily Functions
Consuming moderate amounts of caffeine (40–300 mg) increases alertness and reduces fatigue. These effects are particularly noticeable in people unaccustomed to caffeine or after short periods of abstinence in regular users.
Caffeine has been shown to improve alertness and vigilance during prolonged tasks, such as long-distance driving. It is also added to some pain relievers to enhance their effectiveness. However, caffeine does not compensate for performance issues caused by prolonged sleep deprivation.
Consuming caffeine late in the day negatively affects sleep quality and increases the time required to fall asleep. It may also induce feelings of anxiety, especially when consumed in doses exceeding 200 mg at a time or 400 mg per day. This is more pronounced in individuals sensitive to caffeine or those with bipolar disorder, with effects varying significantly from person to person.
High caffeine intake promotes diuresis, although no adverse effects on fluid balance in the body have been observed with long-term moderate consumption of less than 400 mg daily. Withdrawal from caffeine after regular consumption can cause disturbances such as fatigue, headaches, mood swings, reduced alertness, and flu-like symptoms. These withdrawal effects peak after one or two days and may last up to nine days, so gradual caffeine reduction is recommended.
Drinking coffee or tea does not affect blood pressure, even in individuals with hypertension. The compound cafestol, which raises cholesterol levels, is more concentrated in unfiltered coffee, such as Turkish or Scandinavian coffee. Consuming up to six standard cups (approximately 235 ml) of filtered coffee is not associated with an increased risk of cardiovascular problems. Drinking three to five cups of coffee reduces the risk of cardiovascular diseases.
Caffeine's Impact on Other Bodily Functions
Caffeine suppresses appetite, thereby improving metabolic rates. Increased caffeine consumption helps limit long-term weight gain. Limited evidence suggests a positive effect of caffeine on body fat. However, high-calorie beverages like soft drinks, energy drinks, or adding sugar to coffee and tea may lead to weight gain.
Caffeine temporarily reduces insulin function. However, drinking four to five cups of coffee daily for six months does not impact insulin levels and reduces the risk of type 2 diabetes.
Numerous studies with strong evidence have shown no link between caffeine consumption and an increased risk of cancer, as previously believed. In fact, coffee has been found to slightly reduce the risk of skin, breast, and prostate cancers and significantly decrease the risk of liver and endometrial cancers.
Caffeine improves liver health and lowers the risk of cirrhosis. Coffee also reduces the likelihood of gallstones and gallbladder cancer and lowers the risk of kidney stones. Additionally, it decreases the risk of Parkinson's disease, depression, and suicide.
Drinking coffee is not associated with memory loss or Alzheimer's disease. Consuming two to five cups of coffee daily improves the quality of life for individuals without a history of chronic illnesses.
Effects of Excessive Caffeine Consumption
Anxiety, restlessness, and discomfort
Insomnia and nervousness
Overexcitement and psychological agitation
Speech tremors
Consuming 1.2 grams of caffeine is considered toxic, while 10–14 grams is fatal. Fatal doses are rarely reached through traditional sources such as coffee and tea. Overdose-related deaths have been linked to caffeine pills or supplements, commonly used by athletes or individuals with psychological disorders.